definitely depends on the game. GTA? Works fine with any genre since they have stations with different genres as it is (but should only be played when inside the cars). Hustle Kings? Works great with George Thorogood. Some games I dont want to have custom soundtracks because the score in-game adds to the atmosphere. Case in point? Uncharted 1 and 2. I think custom soundtracks will only work with a select few genres really. I think the only ones I would consider custom soundtracks on are games like Hustle Kings, racing titles, sports games, etc. Not everything under the sun, though